Buddha Basnyat, David R Murdoch High- altitude illness is the collective term for acute mountain sickness (AMS), high altitude cerebral oedema (HACE), & high altitude pulmonary oedema (HAPE).the pathophysiology of these syndromes is not completely understood, although studies have substantially contributed to the current  understanding of several areas. These areas include the role & potential mechanishms of brain swelling in AMS & HACE mechanisms accounting for exaggerated pulmonary hypertention in HAPE, & the role of inflammation & alveolar-fluid clearance in HAPE. Only limited information is available about the genetic basis of high-altitude illness, & no clear associations between gene polymorphisms &... Continue reading

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